Sophia Domancich began her musical studies at the age of six. She graduated from the Conservatoire National de Paris with a First Prize in piano and a First Prize in chamber music. From 1975 to 1990, she taught at the Conservatoire du Xème arrondissement de Paris.
She discovered jazz and improvisation alongside Steve Lacy and Laurent Cugny, who invited her to join his Big-Band Lumière.
From 19991, Sophia Domancich played her own compositions in trio with Paul Rogers and Tony Levin, and regularly appeared on the British scene, alongside Elton Dean, Robert Wyatt,
Hugh Hopper, Pip Pyle and Evan Parker. From 1997 to 2000, she joined the Orchestre National de Jazz, directed by Didier Levallet.
Since 2001, she has taken part in numerous groups, including a trio with John Greaves and Vincent Courtois, the Soft bounds quartet ( with former members of the legendary Soft Machine), DAG (a trio formed with Jean-Jacques Avenel and Simon Goubert, with whom she also plays in a duo), A riot called Nina, a group led by Napoleon Maddox, a trio with Ramon Lopez and Joelle Léandre, or African Jazz Roots with Ablaye Cissoko.
France Musique commissions her to write a piece for the Alla Breve program. She produced "De 3H à 5H", and "Lilienmund", a piece for piano and electro-acoustics, premiered at Radio France
as part of the Présence festival.
In 2011, "Snakes and ladders" an atypical album for which she invited Himiko Paganotti and Robert Wyatt, among others, was nominated for a "Victoires du Jazz" award. In 2009, Sophia Domancich formed Pentacle with Claude Tchamichian, Jean-Luc Cappozzo and Michel Marre. She then recorded two trio albums: "Washed away" with Hamid Drake and William Parker in 2011, and "Courte pointe" with Andrew Cyrille and Mark Helias. To complete this trilogy on the Futura Marge label, "Alice's Evidence" with Géraldine Laurent, Hélène Labarrière, Nasheet Waits and Ray Anderson was released in 2016.
In 2021, she will release her second solo album, "le grand jour", as well as a second album in duo with Simon Goubert : "Twofold head".
Currently, Sophia Domancich also performs with the trio Les jours rallongent with Christiane Bopp and Denis Charolles, as well as with Christophe Monniot's quartet. Her new trio album "Wishes" will be released in November 2025, with Mark Helias and Eric McPherson.
In 1999, Sophia Domancich was awarded the Prix Django Reinhardt by the Académie du jazz.